ChemInform Abstract: Synthesis of Sibutr
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J. E. JEFFERY; F. KERRIGAN; T. K. MILLER; G. J. SMITH; G. B. TOMETZKI
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Article
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2010
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John Wiley and Sons
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Synthesis of Sibutramine, a Novel Cyclobutylalkylamine Useful in the Treatment of Obesity, and Its Major Human Metabolites. -A short and convenient pathway to sibutramine (VII) and some of its demethylated (cf. (V)) and hydroxylated (cf. (XI)) human metabolites is presented. One of the key steps is