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ChemInform Abstract: A Novel Stereoselective Route to Some Uncommon Amino Acids.

✍ Scribed by Clay Pearson; Kenneth L. Rinehart; Michihiro Sugano


Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis


A Novel Stereoselective Route to Some Uncommon Amino Acids.

-An efficient synthesis of the D-erythro-Ξ²-methylaspartic acid analogue (VIII) is achieved in six steps. Evans' aldol reaction is utilized followed by Weinreb amide formation and Mitsunobu inversion to achieve the necessary stereochemistry of the amino acid target. The technique is applied to the synthesis of a racemic diaminobutyric acid derivative (XI), too. -(PEARSON,


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