ChemInform Abstract: A Novel Approach to Retrosynthetic Analysis Using Knowledge Bases Derived from Reaction Databases.

ChemInform Abstract: A Versatile Approac

ChemInform Abstract: A Versatile Approach to 2-Substituted 3-Trifluoromethyl-1,3-diols Based on the Reaction of Trifluoroacetaldehyde Ethyl Hemiacetal with Enamines Derived from Aldehydes.

✍ Kazumasa Funabiki; Yudai Furuno; Fumiaki Sato; Hiroshi Gonda; Yasuhiro Kubota; M 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 79 KB

## Abstract The reaction of enamine (I) with ethyl hemiacetal (II) followed by acid hydrolysis and subsequent reduction of the intermediate aldehyde gives rise to the diastereomeric mixture of diols (III) and (IV).