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ChemInform Abstract: A Novel Approach for Total Synthesis of Cryptophycins via Asymmetric Crotylboration Protocol.

โœ Scribed by U. P. DHOKTE; V. V. KHAU; D. R. HUTCHISON; M. J. MARTINELLI

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
30
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

A Novel Approach for Total Synthesis of Cryptophycins via Asymmetric Crotylboration Protocol. -Crotylboration of aldehyde (I) with the ฮฑ-pinene-derived boron reagent (II) provides the optically pure alcohol (IV) after oxidative work-up. Compound (IV) is linearly converted to the fragment A (V) of the cryptophycins. Following stepwise coupling with three fragments provides the cryptophycin A derivative (VI). -(DHOKTE, U.

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ChemInform Abstract: Total Synthesis of Clerocidin via a Novel, Enantioselective Homoallenylboration Methodology.
โœ A. X. XIANG; D. A. WATSON; T. LING; E. A. THEODORAKIS ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 30 KB ๐Ÿ‘ 2 views

Total Synthesis of Clerocidin via a Novel, Enantioselective Homoallenylboration Methodology. -The key steps in the synthesis of the title compound (VI) are stereoselective homoallenylboration of the aldehyde (II) and regio-and stereoselective epoxidation of the resulting diene (IV). -(XIANG, A. X.;