ChemInform Abstract: A New Stereoselective Synthesis of Chiral γ-Functionalized (E)- Allylic Amines.
✍ Scribed by G. REGINATO; A. MORDINI; F. MESSINA; A. DEGL'INNOCENTI; G. POLI
- Book ID
- 112041414
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 34 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Baylis—Hillman adducts (I) react regio‐ and stereoselectively with various primary aliphatic amines under neat conditions to potentially valuable building blocks containing reactive C—C double bonds and an ester and cyano group, respectively.
Stereoselective Synthesis of Chiral γ-Hydroxy-β-methyl Methylcarbinols. -The reaction proceeds in three steps: regioselective hydroboration, oxidation, and reduction to the final products. The protocol can find useful applications in the synthesis of natural products. -