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ChemInform Abstract: A New Practical Synthesis of Linezolid: An Antibacterial Drug.

โœ Scribed by Ganta Madhusudhan Reddy; Akula Ramulu; Padi Pratap Reddy

Publisher
John Wiley and Sons
Year
2010
Weight
22 KB
Volume
41
Category
Article
ISSN
0931-7597

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ChemInform Abstract: A Short Synthesis o
ChemInform Abstract: A Short Synthesis of Oxazolidinone Derivatives Linezolid and Eperezolid: A New Class of Antibacterials.
โœ Braj B. Lohray; Sundarababu Baskaran; B. Srinivasa Rao; B. Yadi Reddy; I. Negesw ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 31 KB ๐Ÿ‘ 2 views

Starting from the D-mannitol derivative (I), a straightforward synthesis of the chiral oxazolidines (VII) including precursors (VIIb) and (VIIc) of linezolid and eperezolid is detailed. Furthermore, the azide (VIIb) is converted to linezolid (IX) with thioacetic acid.