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ChemInform Abstract: A New Approach to the Synthesis of Di- and Tripeptides with Unnatural Amino Acids Using Organozinc Chemistry.

โœ Scribed by M. J. DUNN; R. F. W. JACKSON


Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
29
Category
Article
ISSN
0931-7597

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โœฆ Synopsis


A New Approach to the Synthesis of Di-and Tripeptides with Unnatural Amino Acids Using Organozinc Chemistry.

-Di-and tripeptides which incorporate an iodoalanine unit can be converted into the corresponding organozinc reagents, which react with electrophiles either under palladium catalysis, or by prior transmetalation to a zinc/copper reagent to give di-and tripeptides incorporating non-proteinogenic amino acids without loss of stereochemical purity. -(DUNN, M.


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