๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

ChemInform Abstract: A New [4 + 2] Cycloaddition Strategy for the Synthesis of N-Acyl-7-azabicyclo[2.2.1]heptan-2-ones: A Formal Synthesis of (.+-.)-Epibatidine.

โœ Scribed by M. L. TRUDELL; N. P. PAVRI

Publisher
John Wiley and Sons
Year
2010
Weight
36 KB
Volume
29
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.

โœฆ Synopsis

A New [4 + 2] Cycloaddition Strategy for the Synthesis of N-Acyl-7-azabicyclo[2.2.1]heptan-2-ones:

A Formal Synthesis of (ยฑ)-Epibatidine.

-The title compound (VIII), an intermediate for the preparation of (ยฑ)-epibatidine, is prepared via Diels-Alder reaction of allenes with N-acylated pyrrole (II). -(

๐Ÿ“œ SIMILAR VOLUMES

ChemInform Abstract: New Synthesis of 7-
ChemInform Abstract: New Synthesis of 7-(tert-Butoxycarbonyl)-7-azabicyclo[2.2.1]hept-2-ene. A Key Intermediate in the Synthesis of Epibatidine and Analogues.
โœ L. E. BRIEADDY; F. LIANG; P. ABRAHAM; J. R. LEE; F. I. CARROLL ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 31 KB

New Synthesis of 7-(tert-Butoxycarbonyl)-7-azabicyclo[2.2.1]hept-2-ene. A Key Intermediate in the Synthesis of Epibatidine and Analogues. -In continuation of efforts on efficient synthetic routes to the alkaloid epibatidine (V), an improved procedure for the synthesis of the N-Boc protected azabicy