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ChemInform Abstract: A Modular Approach to Large Functional Structures

โœ Scribed by David N. Reinhoudt; Dmitry M. Rudkevich; Wilhelm T. S. Huck; Paul J. A. Kenis; Remko H. Vreekamp


Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
30
Category
Article
ISSN
0931-7597

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ChemInform Abstract: A Convergent Approa
โœ J. BOIVIN; S. HUPPE; S. Z. ZARD ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 34 KB

The convergent approach to a broad variety of functionalized alkynes starts with a Knoevenagel-type condensation of 4-unsubstituted isoxazolines with ketones or aldehydes. The resulting adducts are subjected to Michael addition with various nucleophiles such as hydride, cyanide or phosphite. Exposur