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ChemInform Abstract: A Facile Synthesis of Fluorine-Containing Heterocycles — Use of 1,1,1-Trifluoro-2-alkanones as a Convenient Synthetic Intermediate.

✍ Scribed by Yasuhiro Kamitori

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
32
Category
Article
ISSN
0931-7597

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✍ E. OKADA; T. KINOMURA; H. TAKEUCHI; M. HOJO 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB 👁 2 views

A Facile and Convenient Synthetic Method for Fluorine-Containing 1,2-Dihydropyrimidines and Pyrimidines. -Base-mediated condensation of the amine (I) with a variety of aldehydes (II) generates the dihydropyrimidines (III) which are easily dehydrogenated to the pyrimidines (IV) in good yields. The m