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ChemInform Abstract: A Facile Anellation of Pyridines with Nitriles of α,β-Acetylenic γ-Hydroxyacids.

✍ Scribed by Boris A. Trofimov; Ludmila V. Andriyankova; Sergei A. Zhivet'ev; Anastasiya G. Mal'kina; Vladimir K. Voronov


Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
33
Category
Article
ISSN
0931-7597

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A facile annelation of pyridines with ni
✍ Boris A Trofimov; Ludmila V Andriyankova; Sergei A Zhivet'ev; Anastasiya G Mal'k 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 89 KB

Pyridines are readily annelated with nitriles of a,b-acetylenic g-hydroxyacids under mild conditions (ambient temperature, no catalyst, no solvent) to give new condensed dihydropyridine systems, 4-cyanomethylidene-1,3-oxazolidine[3,2-a]-1,2-dihydropyridines in 75-83% yields.