A Diastereoselective Radical Cyclization Approach to Pyroglutamates. -The 5-endo radical cyclization of pyruvic acid derived dehydroalanines (VI) possessing chiral ester auxiliaries is reported. The diastereoselectivity can be increased up to 6:1 by cyclization of the corresponding 8-phenylmenthyl
ChemInform Abstract: A Diastereoselective Intramolecular Hydroamination Approach to the Syntheses of (+)-, (.+-.)-, and (-)-Pinidinol.
β Scribed by Gary A. Molander; Eric D. Dowdy; Shawn K. Pack
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
The pyrazole aldehyde (I) undergoes Knoevenagel condensations with heterocycles to yield adducts, which are directly thermolyzed to cyclize via hetero Diels-Alder reactions to cis-fused tetracyclic title heterocycles. Interestingly, the isoxazolo-fused cycloadduct (VII) is converted to the spiro-azi