A convergent synthesis of the pentapeptide poststatin has been developed. The key step involves oxidative cleavage of an aeyl cyanophosphorane. The resulting a,/3-diketo nitrile is then coupled to the free amine of a C-tenninal-dipoptidyl component to generate the protected natural product. Deprotec
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ChemInform Abstract: A Convergent Synthesis of Poststatin: Application of the Acyl Cyanophosphorane Coupling Procedure in the Formation of a Peptidic . alpha.-Keto Amide.
β Scribed by H. H. WASSERMAN; A. K. PETERSEN
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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