ChemInform Abstract: A Convenient Synthesis of 3-Nitro-2-pyrrolines: Regioselective Oxidations of Substituted Pyrrolidines to Pyrrolines.

✍ Scribed by L. K. BAJPAI; A. P. BHADURI

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199821103

✦ Synopsis

A Convenient Synthesis of 3-Nitro-2-pyrrolines: Regioselective Oxidations of Substituted Pyrrolidines to Pyrrolines. -The title reaction is most favorably carried out using KMnO 4 in the presence of K 2 CO 3 . If NaHCO 3 is used as a base in addition to products (II) hydroxymethyl derivatives (IV) and (V) are also formed. This is explained by participation of methanol in the oxidation reaction yielding formaldehyde, which undergoes hydroxymethy-