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ChemInform Abstract: 3,8-Diazabicyclo-[3.2.1]-octane Derivatives as Analogues of Ambasilide, a Class III Antiarrhythmic Agent.

โœ Scribed by Stefanie Villa; Daniela Barlocco; Giorgio Cignarella; Gyula Julius Papp; Beata Balati; Janos Takacs; Andras Varro; Andras Borosy; Katalin Keseru; Peter Matyus


Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
33
Category
Article
ISSN
0931-7597

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Trimethylpiperazines as Monocyclic Analogues of the . mu.-Opioid Agonist 3,8-Diazabicyclo(3.2.1)octanes: Synthesis, Modeling, and Activity. -The trimethylpiperazine derivatives (IV)-(VII) are tested in binding studies for ยต-opioid receptors. Their different affinity towards . mu.-opioid receptors i