Enantiomers of 3-methylazetidin-2-one -(3R)-(+)-and (3S)-(-)-1 and of 3-amino-2methylpropionic acid -(2R)-(-)-and (2S)-(+)-2 were obtained from corresponding diastereomers of methyl (ty.S)-N-t~-methylbenzyl-3-amino-2-methylpropionate 3A,B which had been separated by recrystallization of their salts
ChemInform Abstract: 3-Methylazetidin-2-one and Its Precursors: Optical Resolution and Absolute Configurations.
โ Scribed by G. V. SHUSTOV; A. RAUK
- Book ID
- 112034575
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Dedicated to Professor George BLichi on the occasion of his 65th birthday Summary: Optical resolution of (?)-tricarbonyl(2,3-dihydrotropone)iron was carried out, and the absolute configuration was determined by X-ray diffraction and CD spectroscopic studies.
The racemic title bicycle (V) undergoes spontaneous resolution on crystallization from chloroform or acetone. The absolute configuration of the obtained enantiopure product (16-44% e.e.) is determined by comparison with (S)-(V) derived from (S)-Ser-OMe (I). Mutarotation due to partial conversion of