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ChemInform Abstract: 2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic Acid Anhydride. A Novel and Highly Potent Antiinflammatory and Cytoprotective Agent.

✍ Scribed by Tadashi Honda; Eric M. Padegimas; Emilie David; Chitra Sundararajan; Karen T. Liby; Charlotte Williams; Michael B. Sporn; Melean Visnick

Publisher
John Wiley and Sons
Year
2010
Weight
18 KB
Volume
41
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

Title compound (I) is easily synthesized as first example of an oleane triterpenoid anhydride.

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ChemInform Abstract: Synthesis and Biological Evaluation of 1-[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A Novel and Highly Potent Antiinflammatory and Cytoprotective Agent.
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## Abstract A small series of new N‐acyl(acetylenic)imidazole analogues (I) is synthesized and evaluated for their anti‐inflammatory and cytoprotective activity.