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ChemInform Abstract: 1β-Hydroxylation in 5β-Steroids: An Efficient Synthesis of 1β,3α-Dihydroxy-5β-cholan-24-oic Acid.

✍ Scribed by Takeru Yamaguchi; Ryusei Nakamori; Takashi Iida; Toshio Nambara


Publisher
John Wiley and Sons
Year
2010
Weight
36 KB
Volume
32
Category
Article
ISSN
0931-7597

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## Abstract A short, practical, multigram‐scale synthesis of C3α‐NHAlloc, C12α‐NHBoc‐diamino‐5β‐cholan‐24‐oic acid **2** was developed, applying a new, straightforward synthetic strategy. Key features are the conservation of the carboxyl moiety at C24 during oxime reduction, the late differentiatio