## Abstract Enantiomeric discrimination is observed in the ^1^H and ^13^C NMR spectra of secondary and tertiary amines in the presence of (−)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid (**1**). Nonequivalence of the resonances of prochiral nuclei in primary and secondary amines is also observed wh
✦ LIBER ✦
ChemInform Abstract: (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid and Its Ytterbium(III) Complex as Chiral NMR Discriminating Agents
✍ Scribed by Thomas J. Wenzel; Jolene E. Thurston
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 26 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Flecainide, an antiarrythmic agent, and its analogs were resolved on a high performance liquid chromatographic chiral stationary phase (CSP) based on (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid with the use of a mobile phase consisting of methanol‐acetonitrile‐trifluoroacetic acid‐t