Chemiluminescence as diagnostic tool. A review

✍ Scribed by Dodeigne C., Thunus L., Lejeune R.

Tongue: English
Leaves: 25
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Talanta 51 (2000) 415–439

Abstract
The principles of chemiluminescence and its applications as diagnostic tool are reviewed. After an introduction to the theoretical aspects of luminescence and energy transfer, the different classes of chemiluminogenic labels including luminol, acridinium compounds, coelenterazine and analogues, dioxetanes, systems based on peroxyoxalic acid and their derivatives are described emphasizing the molecules which best fulfil the requirements of today’s clinical chemistry. Applications of hemiluminescence and enhanced chemiluminescence to immunoassays, receptor assays, DNA probes, biosensors and oxygen metabolism are discussed as well as the role of enzymes in the selectivity and the sensitivity of these reactions.

Keywords: Enhanced chemiluminescence; Chemiluminogenic labels; Chemiluminescent assays; Oxygen metabolites

✦ Subjects

Химия и химическая промышленность;Фото- и радиационная химия

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