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Chemical toxicity testing in vitro using cytochrome P450–expressing cell lines, such as human CYP1B1

✍ Scribed by Landsiedel, Robert; Fabian, Eric; Tralau, Tewes; Luch, Andreas

Book ID: 109946898
Publisher: Nature Publishing Group
Year: 2011
Tongue: English
Weight: 909 KB
Volume: 6
Category: Article
ISSN: 1750-2799
DOI: 10.1038/nprot.2011.316

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## Abstract A human lymphoblastoid cell line stably expressing a human cytochrome P4501A2 cDNA was developed. This recombinant cell line displayed P4501A2 protein and estradiol2‐hydroxylase activity, neither of which was detected in the parental cell line. The recombinant cell line was also approxi