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Chemical synthesis of the phosphonic acid analogue of Sphingomyelin — ceramide-N,N,N,-trimethyl-amino-ethyl phosphonate

✍ Scribed by V.M. Kapoulas; M.C. Moschidis


Book ID
103042041
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
273 KB
Volume
21
Category
Article
ISSN
0009-3084

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✦ Synopsis


In 1969 Baer and Sarma repolted the total synthesis ofceramide aminoethv~ phosphonate (CAEP) and of its enantiomer [ I ]. ~'I~s compound had been


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Synthesis of a Phosphonic Acid Analogue
✍ Andrea Vasella; René Wyler 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 German ⚖ 922 KB

Obtained in five steps from N-acetylneuraminic acid (Neu5Ac) according to known procedures [3]. Zto and Ogawa indicate a ratio 12/13 of 1:4.1 [lo]. Such a neighbouring group participation [ 121 and particularly the formation of 6,8-dioxa[3.2.l]bicyclooctane structures similar to 15 have been describ