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Chemical synthesis of phosphorylated fundamental structure of lipid a

โœ Scribed by Masaru Inage; Haruyuki Chaki; Shoichi Kusumoto; Tetsuo Shiba


Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
253 KB
Volume
22
Category
Article
ISSN
0040-4039

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๐Ÿ“œ SIMILAR VOLUMES


Chemical synthesis of phosphorylated tet
โœ M. Imoto; H. Yoshimura; M. Yamamoto; T. Shimamoto; S. Kusumoto; T. Shiba ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 296 KB

A total synthesis of 2,2'-N; 3,3'-O-tetraquis[(R)-3-hydroxytetradecanoyl]-~(l-6)-Dglucosamine disaccharide 1,4'-diphosphate is described. This is the first confirmation of the fundamental structure of lipid A since the synthetic compound exhibited most of the characteristic biological activities of

Chemical synthesis of 5โ€ฒ-phosphorylated
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A highly hydrophobic N-methoxytrityloxyethylaniline(MTEA) was introduced for the protection of 5 '-phosphate of thymidine. A MTEA group at the phosphodiester level is cleaved by aqueous acetic acid. By using MTEA group, 5'-phosphorylated hexadecadeoxyribonucleotide was rapidly synthesized on a polym