Chemical Synthesis of Phase-I- and Phase-II-Metabolites of Antipyrine
✍ Scribed by K. Krohn; C. Stenns
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 412 KB
- Volume
- 322
- Category
- Article
- ISSN
- 0365-6233
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📜 SIMILAR VOLUMES
Simultaneous O-demethylation and hydrogen/deuterium exchange of aryl-methylethers can be obtained using 1-[ 2 H]-pyridinium hydrochloride as reagent at 2208C for 6 h. This reaction was applied to dextromethorphan and various non-steroidal antiinflammatory drugs.
## Abstract Derivatization with 1,2‐dimethylimidazole‐4‐sulfonyl chloride (DMISC) has been successfully used as a tool to differentiate between aromatic and aliphatic __O__‐glucuronides of hydroxypropranolol. The analyses were performed with liquid chromatography–electrospray ionization–tandem mass