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Chemical synthesis of deuterium-labeled and unlabeled very long chain polyunsaturated fatty acids

✍ Scribed by Ghulam M. Maharvi; Albert O. Edwards; Abdul H. Fauq


Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
356 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis


First syntheses of a deuterium-labeled very long C34-containing polyunsaturated fatty acid, 34:5n5, and three other unlabeled very long chain C30-32 containing polyunsaturated fatty acids are reported. These syntheses were achieved by coupling chemically modified C22-and C20-containing polyunsaturated fatty acids with carbanions derived from arylalkyl sulfones, followed by sodium amalgam-mediated desulfonylation.


πŸ“œ SIMILAR VOLUMES


Stereoselective synthesis of unsaturated
✍ Julie Defretin; Jairo Saez; Xavier Franck; Reynald Hocquemiller; Bruno FigadΓ¨re πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 222 KB

Very long chain fatty acids are isolated from many different natural sources. However their unsaturated and particularly their diunsaturated derivatives with a k n,"+4 pattern are almost exclusively encountered in marine organisms, until we fimnd some derivatives in the botanical family of the Annon