Chemical synthesis of deuterium-labeled and unlabeled very long chain polyunsaturated fatty acids
β Scribed by Ghulam M. Maharvi; Albert O. Edwards; Abdul H. Fauq
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 356 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
First syntheses of a deuterium-labeled very long C34-containing polyunsaturated fatty acid, 34:5n5, and three other unlabeled very long chain C30-32 containing polyunsaturated fatty acids are reported. These syntheses were achieved by coupling chemically modified C22-and C20-containing polyunsaturated fatty acids with carbanions derived from arylalkyl sulfones, followed by sodium amalgam-mediated desulfonylation.
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Very long chain fatty acids are isolated from many different natural sources. However their unsaturated and particularly their diunsaturated derivatives with a k n,"+4 pattern are almost exclusively encountered in marine organisms, until we fimnd some derivatives in the botanical family of the Annon