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Chemical structure of E. Coli Lipid A: Linkage site of acyl groups in the disaccharide backbone

✍ Scribed by M. Imoto; S. Kusumoto; T. Shiba; H. Naoki; T. Iwashita; E.Th. Rietschel; H.-W. Wollenweber; C. Galanos; O. Lüderitz

Publisher: Elsevier Science
Year: 1983
Tongue: French
Weight: 264 KB
Volume: 24
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)88251-9

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✦ Synopsis

The structure of the lipid A component of E. & lipopolysaccharide was determined by means of chemical and 2D-NMR methods unequivocally to be a glucosamine B(l'-6)-disaccharide 1,4'-diphosphate acylated at the two hydroxyl (positions C-3 and -3') and the two amino groups. Lipid A, which represents the lipophilic portion of bacterial lipopolysaccharides (LPS),

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