✦ LIBER ✦

Chemical Strategies for Activity-Based Proteomics

✍ Scribed by Anna E. Speers; Benjamin F. Cravatt

Book ID: 101819968
Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 193 KB
Volume: 5
Category: Article
ISSN: 1439-4227
DOI: 10.1002/cbic.200300721

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The assignment of molecular and cellular functions to the numerous protein products encoded by prokaryotic and eukaryotic genomes presents a major challenge for the field of proteomics. To address this problem, chemical approaches have been introduced that utilize small‐molecule probes to profile dynamics in enzyme activity in complex proteomes. These strategies for activity‐based protein profiling enable both the discovery and functional analysis of enzymes associated with human disease.

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