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Activity-based proteomics: enzyme chemistry redux

✍ Scribed by John W Kozarich

Book ID
104414625
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
143 KB
Volume
7
Category
Article
ISSN
1367-5931

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✦ Synopsis

The principles of enzyme chemistry, mechanism of action and inhibitor design are being applied to proteomics by the development of activity-based probes. This approach suggests a potentially broad method for interrogating enzyme family members, both known and unknown, in cells and proteomic fractions without the need for individual assay development and isolation. The serine hydrolases and cysteine proteases have provided the proofs of concept for activity-based proteomics, and other studies are rapidly following. The result will be a proteomics technology of great value to drug discovery and development.

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Chemical Strategies for Activity-Based Proteomics
✍ Anna E. Speers; Benjamin F. Cravatt πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 193 KB

## Abstract __The assignment of molecular and cellular functions to the numerous protein products encoded by prokaryotic and eukaryotic genomes presents a major challenge for the field of proteomics. To address this problem, chemical approaches have been introduced that utilize small‐molecule probe