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Chemical oxidation of an anticonvulsant N-(5′-methylisoxazol-3-yl)-2,6-dimethylbenzamide (D2916)

✍ Scribed by S. Adolphe-Pierre; S. Ménager; F. Tombret; Ph. Vérité; F. Lepage; O. Lafont

Book ID
114019405
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
704 KB
Volume
53
Category
Article
ISSN
0014-827X

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An expedient synthesis of (±)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid hydrobromide via a 3-bromoisoxazole intermediate
✍ Robert N. Hanson; Farid A. Mohamed 📂 Article 📅 1997 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 277 KB

## Abstract The excitatory, amino acid ±2‐amino‐3‐(3‐hydroxy‐5‐methylisoxazol‐4‐yl)propionic acid hydrobromide was prepared in gram quantities in an 3.3% overall yield from methylbut 2‐ynoate. The key step was the facile preparation of methyl 3‐bromo‐5‐methylisoxazole‐4‐carboxylate.