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Chemical Modification of Nucleic Acids Toward Functional Nucleic Acid Systems

✍ Scribed by Natarajan Venkatesan; Young Jun Seo; Eun Kyoung Bang; Sun Min Park; Yoon Suk Lee; Byeang Hyean Kim

Publisher
John Wiley and Sons
Year
2006
Weight
8 KB
Volume
37
Category
Article
ISSN
0931-7597

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Chemical stability of nucleic acid–deriv
Chemical stability of nucleic acid–derived drugs
✍ Dariusz Pogocki; Christian SchΓΆneich πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 344 KB πŸ‘ 1 views

Nucleic acid-derived drugs exhibit both chemical and physical instability. This mini-review focuses on the prevalent hydrolytic and oxidative pathways of chemical degradation as they are affected by various endogenous (primary structure, chemical modifications in bases, sugars and phosphate residues