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Chemical stability of nucleic acid–derived drugs

✍ Scribed by Dariusz Pogocki; Christian Schöneich

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
344 KB
Volume
89
Category
Article
ISSN
0022-3549

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✦ Synopsis

Nucleic acid-derived drugs exhibit both chemical and physical instability. This mini-review focuses on the prevalent hydrolytic and oxidative pathways of chemical degradation as they are affected by various endogenous (primary structure, chemical modifications in bases, sugars and phosphate residues) and exogenous (pH, buffer concentration, metal cation presence, oxygen presence) factors.

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