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Chemical modification of erythromycin A: Synthesis of the C1–C9 fragment from erythromycin A and reconstruction of the macrolactone ring

✍ Scribed by Atsushi Nishida; Kikuno Yagi; Norio Kawahara; Mayumi Nishida; Osamu Yonemitsu


Book ID
103407433
Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
252 KB
Volume
36
Category
Article
ISSN
0040-4039

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Synthesis and stereochemical assignment
✍ K.C. Nicolaou; Kyo Han Ahn 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 284 KB

Compound 8 representing fhe Ct-CtO fragment of nystafin At has been synthesized from nystafin Af by degradation and by total synthesis. Comparison of the two samples revealed the 3R, 5R, 7R stereochemistry for the three nystafin A I centers. Nystatin At (I)1 is a clinically used polyene macrolide