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Chemical Engineering of Enzymes: Altered Catalytic Activity, Predictable Selectivity and Exceptional Stability of the Semisynthetic Peroxidase Seleno-Subtilisin

✍ Scribed by Häring, Dietmar; Schreier, Peter

Book ID
113016888
Publisher
Springer
Year
1999
Tongue
English
Weight
104 KB
Volume
86
Category
Article
ISSN
0028-1042

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πŸ“œ SIMILAR VOLUMES

Novel Biocatalysts by Chemical Modificat
Novel Biocatalysts by Chemical Modification of Known Enzymes: Cross-Linked Microcrystals of the Semisynthetic Peroxidase Seleno-Subtilisin
✍ Dietmar HΓ€ring; Peter Schreier πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 96 KB

The linkage of lysine residues on the surfaces of subtilisin crystals (NH -Enz; see Scheme) with glutardialdehyde affords an immobilized biocatalyst of high stability and purity. The replacement of the serine OH group in the active site (Enz-OH) by SeO H leads to new activity as a peroxidase. Thus f