Chemical constituents of gentianaceae XI: Antipsychotic activity of gentianine

✍ Scribed by S. K. Bhattacharya; S. Ghosal; R. K. Chaudhuri; A. K. Singh; P. V. Sharma

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 230 KB
• Volume: 63
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600630850

✦ Synopsis

Phenethylamine Derivatives

EDm (95%

On-Dura-Limits), set, tiqn, Compound m g / k g ip" min mln ( .t) -2-Hydroxy-4,5-17 2-18 2-24 dimethoxyphenethanol-(12.1-23.8) amine (I) enedioxyphenethanolamine (25.4-123.2) (11) ( .t ) -2-Hydroxy-4,5-methyl-56 2-6 2-22 5 . 3 2-14 2-28 Mescaline ( 3 . 6 -7 . 3 ) a The EDLO values reported are calculated for the free base concentrations of the test compounds.

derivatives I and I1 were about one-third and onetenth as active as mescaline, respectively. From these results it appears that I could be an endogenous psychotogen responsible for schizophrenic manifestations as postulated by Shulgin et al. (4).