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Chemical Constituents from Clerodendrum bungei and Their Cytotoxic Activities

✍ Scribed by Shan-Shan Liu; Tong Zhou; Shu-Wei Zhang; Li-Jiang Xuan

Publisher
John Wiley and Sons
Year
2009
Tongue
German
Weight
193 KB
Volume
92
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

magnified image

A new phenylethanoid glycoside, two new cyclohexylethanoids, one new phenolic glycoside, and a new farnesane‐type sesquiterpenoid, namely 2‐phenylethyl 3‐O‐(6‐deoxy‐α‐L‐mannopyranosyl)‐β‐D‐glucopyranoside (1), 6″‐O‐[(E)‐caffeoyl] rengyoside B (2), clerodenone A (3), 2‐({6‐O‐[(4‐hydroxy‐3‐methoxyphenyl)carbonyl]‐β‐D‐glucopyranosyl}oxy)‐2‐methylbutanoic acid (4), 2‐{(2__S__,5__R__)‐5‐[(1__E__)‐4‐hydroxy‐4‐methylhexa‐1,5‐dien‐1‐yl]‐5‐methyltetrahydrofuran‐2‐yl}propan‐2‐yl β‐D‐glucopyranoside (5), together with 16 known compounds, were isolated from the roots of Clerodendrum bungei. All structures were elucidated by spectroscopic methods. The new compounds showed modest in vitro inhibition of the proliferation of the HeLa human cervical carcinoma cell line (CCL‐2), with IC~50~ values in the range of 3.5–8.7 μM, adriamycin being used as positive control, with an IC~50~ value of 0.026±0.001 μM.

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