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Chemical Constituents of Crinum asiaticum L. var. sinicumBaker and Their Cytotoxic Activities

✍ Scribed by Qian Sun; Yun-Heng Shen; Jun-Mian Tian; Jian Tang; Juan Su; Run-Hui Liu; Hui-Liang Li; Xi-Ke Xu; Wei-Dong Zhang

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
187 KB
Volume
6
Category
Article
ISSN
1612-1872

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✦ Synopsis

Abstract

A phytochemical investigation of the bulbs of Crinum asiaticum L. var. sinicum Baker resulted in the isolation of two new alkaloids, asiaticumines A and B (1 and 2, resp.), together with 21 known compounds, including nine alkaloids, four amides, five phenolic compounds, and three flavonoids. All 23 compounds were isolated for the first time from Crinum asiaticum L. var. sinicum Baker. Their structures were elucidated by spectroscopic methods. In addition, ten alkaloids, 1–10, were evaluated for their cytotoxic activities against human tumor cell lines A549, LOVO, HL‐60, and 6T‐CEM. Compounds 3, 4, and 7–10 selectively showed remarkable inhibition against one or more of the tested cell lines.

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