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Chelation-controlled protocol for the diastereoselective reduction of ketones

โœ Scribed by Sarko, Christopher R.; Guch, Ian C.; DiMare, Marcello


Book ID
126325719
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
249 KB
Volume
59
Category
Article
ISSN
0022-3263

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High 1,6-Diastereoselectivity in the Hydride Reduction of an Acyclic Ketone Substrate via Bicyclic Chelation Control. -Reduction of the .epsilon.-hydroxyketone (I) with (R)-Alpine hydride provides the corresponding diol (II) with strong preponderance of the anti-diastereomer. The high degree of ste