High 1,6-Diastereoselectivity in the Hydride Reduction of an Acyclic Ketone Substrate via Bicyclic Chelation Control. -Reduction of the .epsilon.-hydroxyketone (I) with (R)-Alpine hydride provides the corresponding diol (II) with strong preponderance of the anti-diastereomer. The high degree of ste
โฆ LIBER โฆ
High 1,6 diastereoselectivity in the hydride reduction of an acyclic ketone substrate via bicyclic chelation control
โ Scribed by Han-Cheng Zhang; Bruce D. Harris; Cynthia A. Maryanoff; Bruce E. Maryanoff
- Book ID
- 103406793
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 263 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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Swnmmy: A variety of educing agents was explored to &act stereoselective nduction of acyclic Shydroxy ketone 3a; R-Alpine-Hydride pmvided high aM sterwaelectivity (unci:syn = 7: 1). Reduction of 3b in cl-&cl2 with R-Alpine-Hydri& or Zn(BH& affo&d impressive anti smleetivity: 1O:l and 13:1, respectiv