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CHEK2:1100delC and female breast cancer in the United States

✍ Scribed by Lutécia H. Mateus Pereira; Alice J. Sigurdson; Michele M. Doody; Marbin A. Pineda; Bruce H. Alexander; Mark H. Greene; Jeffery P. Struewing

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
53 KB
Volume
112
Category
Article
ISSN
0020-7136

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The CHEK2 kinase is a tumor suppressor whose activation in response to DNA double-strand breaks contributes to cell cycle arrest or apoptosis. The c.1100delC mutation is associated with familial breast cancer, and tumors from mutation carriers show reduced or absent CHEK2 protein expression. We have