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Characterizing genetically stable and unstable gastric cancers by microsatellites and array comparative genomic hybridization

✍ Scribed by Hanna Vauhkonen; Matti Vauhkonen; Antti Sajantila; Pentti Sipponen; Sakari Knuutila


Book ID
113512985
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
745 KB
Volume
170
Category
Article
ISSN
0165-4608

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By means of comparative genomic hybridization (CGH), we screened 58 primary gastric cancers for changes in copy number of DNA sequences. We detected frequent losses on Ip32-33 (21%), 3p21-23 (22%), 5q14-22 (36%), 6q16 (26%), 9p21-24 (22%), 16q (21%), 17p13 (48%), 18q11-21(33%), and 19(40%). Gains we