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Characterization of the submicroscopic deletion in the small-cell lung carcinoma (SCLC) cell line U2020

✍ Scribed by Dr. Harry A. Drabkin; Mike J. Mendez; Pamela H. Rabbitts; Terry Varkony; Jonas Bergh; Joseph Schlessinger; Paul Erickson; Robert M. Gemmill

Book ID
102845413
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
673 KB
Volume
5
Category
Article
ISSN
1045-2257

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✦ Synopsis

The small-cell lung carcinoma cell line U2020 contains a submicroscopic, homozygous deletion that removes a chromosomal segment within 3p 13-p 14, including the locus D3S3. W e have sublocalized 49 additional probes to the 3p 13-p 14.2 region and have identified 7 new D N A markers that arise from within the U2020 deletion. The estimated size of the deletion, based on marker density, is approximately 4-5 megabases (Mb). Including D3S3, 7 of the 8 markers have been linked by pulsed-field gel (PFG) electrophoresis over an area of approximately 2 Mb. Including the one unlinked marker, PFG analysis accounts for about 3 Mb of the region. The U2020 deletion appears confined to the 3p 13-p 14.2 region and does not include the candidate tumor suppressor gene, protein-tyrosine phosphatase gamma (PTPG). Genes Chrom Cancer 5:67-74 ( I 992). @ 1992 WiIey-Liss. Inc.

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