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Characterization of the phencyclidine-induced increase in prefrontal cortical dopamine metabolism in the rat

โœ Scribed by Asami Umino; Kiyohisa Takahashi; Toru Nishikawa


Book ID
110003600
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
456 KB
Volume
124
Category
Article
ISSN
0007-1188

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The noncompetitive NMDA receptor antagonist phencyclidine (PCP) and the neuronal cannabinoid receptor agonist โŒฌ 9 -tetrahydrocannabinol (THC) are two agents shown to have psychotomimetic properties in humans. Both drugs increase dopamine release and utilization in the prefrontal cortex, a brain regi