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Repeated exposure to Δ9-tetrahydrocannabinol reduces prefrontal cortical dopamine metabolism in the rat

✍ Scribed by J.David Jentsch; Christopher D. Verrico; Dung Le; Robert H Roth


Book ID
117476668
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
140 KB
Volume
246
Category
Article
ISSN
0304-3940

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The noncompetitive NMDA receptor antagonist phencyclidine (PCP) and the neuronal cannabinoid receptor agonist ⌬ 9 -tetrahydrocannabinol (THC) are two agents shown to have psychotomimetic properties in humans. Both drugs increase dopamine release and utilization in the prefrontal cortex, a brain regi