Objective. Allelic TAP polymorphism has been linked to susceptibility to Reiter's syndrome and was suggested to influence disease phenotype in HLA-B27 positive patients with ankylosing spondylitis. In the present study, we examined whether the human TAP alleles functionally differ in their transloca
Characterization of the peptide-binding specificity of HLA-B*7301
β Scribed by L. D. Barber; L. Percival; P. Parham
- Book ID
- 115096668
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 505 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0001-2815
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## Modulation of peptide binding by HLA-B27 polymorphism in pockets A and B, and peptide specificity of B*2703 The results in this study address three aspects of peptide binding to the diseaseassociated antigen HLA-B27 and its modulation by polymorphism: the contribution of major anchor residues 2
Two HLA-B27 subtypes, B'2702 and B'2705, both associated with ankylosing spondylitis, were tested for binding affinity with a panel of polyalanine model nonapeptides carrying Arg at position 2 (P2) and a series of different amino acids at position 9 (P9)\_ The alpha chains were isolated from BTB(B\*