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Characterization of the interaction of plasminogen activator inhibitor type 1 with vitronectin by surface plasmon resonance

✍ Scribed by J. Ehnebom; P. Björquist; O. Sigurdardottir; J. Deinum


Book ID
117836952
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
172 KB
Volume
14
Category
Article
ISSN
0268-9499

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Plasminogen activator inhibitor-1 regula
✍ Gary Deng; Scott A. Curriden; Geng Hu; Ralf-Peter Czekay; David J. Loskutoff 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 247 KB

## Abstract Plasminogen activator inhibitor‐1 (PAI‐1) binds to the somatomedin B (SMB) domain of vitronectin. It inhibits the adhesion of U937 cells to vitronectin by competing with the urokinase receptor (uPAR; CD87) on these cells for binding to the same domain. Although the inhibitor also blocks