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Immunological characterization of type 1 plasminogen activator inhibitor (PAI-1) binding to native and urea-treated vitronectin (VN)

✍ Scribed by S.G. Shaughnessy; T.J. Podor


Book ID
119154604
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
134 KB
Volume
8
Category
Article
ISSN
0268-9499

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## Abstract Plasminogen activator inhibitor‐1 (PAI‐1) binds to the somatomedin B (SMB) domain of vitronectin. It inhibits the adhesion of U937 cells to vitronectin by competing with the urokinase receptor (uPAR; CD87) on these cells for binding to the same domain. Although the inhibitor also blocks