𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Characterization of the Glycosyltransferase Activity of DesVII: Analysis of and Implications for the Biosynthesis of Macrolide Antibiotics

✍ Scribed by Borisova, Svetlana A.; Zhao, Lishan; Melançon, Charles E.; Kao, Chai-Lin; Liu, Hung-wen

Book ID
127160205
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
42 KB
Volume
126
Category
Article
ISSN
0002-7863

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Glycosylation of Acyclic and Cyclic Agly
Glycosylation of Acyclic and Cyclic Aglycone Substrates by Macrolide Glycosyltransferase DesVII/DesVIII: Analysis and Implications
✍ Svetlana A. Borisova; Hak Joong Kim; Xiaotao Pu; Hung-wen Liu 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 256 KB

Macrolides target the bacterial protein translation machinery and are one of the most prescribed classes of antibiotics to treat bacterial infection. [1] However, emerging bacterial resistance to macrolides necessitates the development of new analogues that can potentially be used as drugs. The stru

Functional Analysis of MycE and MycF, Tw
Functional Analysis of MycE and MycF, Two O-Methyltransferases Involved in the Biosynthesis of Mycinamicin Macrolide Antibiotics
✍ Shengying Li; Yojiro Anzai; Kenji Kinoshita; Fumio Kato; David H. Sherman 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 431 KB

## Abstract **Mg motors**: We characterized the in vitro function of MycE and MycF, two __O__‐methyltransferases involved in the biosynthesis of mycinamicin antibiotics. Each enzyme was confirmed to be an __S__‐adenosyl‐L‐methionine (SAM)‐dependent deoxysugar methyltransferase. Their optimal activi