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Characterization of the glucuronide conjugate of cotinine: a previously unidentified major metabolite of nicotine in smokers' urine

✍ Scribed by Caldwell, W. S.; Greene, J. M.; Byrd, G. D.; Chang, K. M.; Uhrig, M. S.; DeBethizy, J. D.; Crooks, P. A.; Bhatti, B. S.; Riggs, R. M.

Book ID
125496625
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
785 KB
Volume
5
Category
Article
ISSN
0893-228X

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Validation and application of a method for the determination of nicotine and five major metabolites in smokers' urine by solid-phase extraction and liquid chromatography–tandem mass spectrometry
✍ David L. Heavner; Joel D. Richardson; Walter T. Morgan; Michael W. Ogden πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 292 KB πŸ‘ 1 views

An SPE-LC-MS/MS method was developed, validated and applied to the determination of nicotine and five major metabolites in human urine: cotinine, trans-3'-hydroxycotinine, nicotine-N-glucuronide, cotinine-N-glucuronide and trans-3'-hydroxycotinine-O-glucuronide. A 500 microL urine sample was pH-adju