Characterization of the expanded T-cell populations in patients with Wegener's granulomatosis
β Scribed by R. GISCOMBE; X. B. WANG; M. KAKOULIDOU; A. K. LEFVERT
- Book ID
- 118700757
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 541 KB
- Volume
- 260
- Category
- Article
- ISSN
- 0954-6820
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## Abstract Wegener's granulomatosis is necrotizing granulomatous vasculitis of unknown origin, which untreated has a high mortality within the first year of onset. The introduction of corticosteroids and cyclophosphamide in the treatment has considerably improved survival rates, but past studies h
## Abstract ## Objective Accumulating data support the role of regulatory T cells, a subset of CD4+ T cells that expresses CD25^high^ and the transcription factor forkhead box P3 (FoxP3), in controlling and preventing autoimmunity. In Wegener's granulomatosis (WG), an autoimmune vasculitis, upβreg