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Abnormalities in T Cell Interactions with the Extracellular Matrix Proteins in a Patient with Wegener's Granulomatosis

✍ Scribed by Andrzej Górski; Janusz Piekarczyk; Henryk Skurzak; Maria Nowaczyk; Beata Dybowska; Barbara Stȩpień-Sopniewska; Graźyna Korczak-Kowalska; Jacek Pazdur; Anna Filipowicz-Sosnowska

Book ID: 115594051
Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 319 KB
Volume: 69
Category: Article
ISSN: 1090-2341
DOI: 10.1006/clin.1993.1163

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## Abstract ## Objective Accumulating data support the role of regulatory T cells, a subset of CD4+ T cells that expresses CD25^high^ and the transcription factor forkhead box P3 (FoxP3), in controlling and preventing autoimmunity. In Wegener's granulomatosis (WG), an autoimmune vasculitis, up‐reg